They were randomized to receive either (i) esomeprazole IV bolus at a dose of 80 mg plus infusion at 8 mg/h for 72 h and oral placebo every 12 h (IVP group), or (ii) IV placebo bolus plus infusion for 72 h and high-dose oral esomeprazole at a dose of 40 mg every 12 h (ORP group)
For continuous infusion, reconstituted esomeprazole at a concentration of 8 mg/ml will be injected at a rate of 1
9%, to give a concentration of 8mg/ml
For the prevention of re-bleeding after an endoscopy, esomeprazole injection is usually
After successful endoscopic haemostatic treatment, eligible patients will be randomized to receive either esomeprazole 80 mg i
72 (upper boundary of 1-sided 95% CI, 0
In study A, the PD of ilaprazole (30 mg) was compared with esomeprazole (80 mg, the maximum single infusion dose of esomeprazole20) in healthy subjects
(Administer within 6 hours if 5% Dextrose Injection is used after reconstitution)
How to take it
With regard to children who weighed at least 40 kg and were older than 12 years of age, the standard adult dose was applied
For continuous infusion, reconstituted esomeprazole at a concentration of 8 mg/ml will be injected at a rate of 1
Esomeprazole 40 mg gastro-resistant capsules, hard - Summary of Product Characteristics (SmPC) Following endoscopic haemostasis, patients received either 80 mg esomeprazole as an intravenous infusion over 30 minutes followed by a continuous infusion of 8 mg per hour for 71
Upper gastrointestinal bleeding (UGIB) is a common medical emergency, with a reported mortality of 2-10%
4 mcg/kg/min Aminophylline (for diuresis) 0
Peptic ulcer bleeding is a common disease and recurrent bleeding is an independent risk factor of mortality
7% versus 22
3: Esomeprazole for intravenous infusion: Prevention of re-bleeding following therapeutic endoscopy for severe bleeding gastric or duodenal ulcers
65 mg is equivalent to 20 mg of esomeprazole base; esomeprazole strontium 49
Protocol violations were reported for five patients (two in the SR6 group received prolonged intravenous esomeprazole infusion because of the clinical need for nothing by mouth, three patients were changed to take other proton pump inhibitors because of patients’ wishes) and were excluded from the PP analysis of the primary end point
administration